| Product Name | Beta - Amyloid (1 - 40) Binding Peptide, Biotin - labeledBiotin - DWGKGGRWRLWPGASGKTEA |
| Size | 1 mg |
| Catalog # | AS-62427 |
| US$ | $197 |
| Purity | % Peak Area By HPLC ≥ 95% |
This 20 amino acid peptide binds to the amyloid form of beta-Amyloid (1-40) but not to monomeric beta-Amyloid (1-40). This sequence represents new potential carrier molecules to deliver medicines to amyloid plaques in AD patients and to image plaques in AD brains. The ability to directly target reagents to the amyloid form of the beta-Amyloid peptide may allow the delivery of neuroprotective agents to make amyloid plaques less toxic, the delivery of amyloid-destroying molecules to eliminate plaques, or the delivery of reagents to prevent amyloid plaque formation. This sequence is biotinylated on the N-terminus. | |
| Detailed Information |  Material Safety Data Sheets (MSDS) |
| Storage | -20°C |
| References | Kang, C. et al. Neurobiol. Dis. 14, 146 (2003). |
| Molecular Weight | 2441.8 |
| Biotin-DWGKGGRWRLWPGASGKTEA | |
| Sequence(Three-Letter Code) | Biotin - Asp - Trp - Gly - Lys - Gly - Gly - Arg - Trp - Arg - Leu - Trp - Pro - Gly - Ala - Ser - Gly - Lys - Thr - Glu - Ala - OH |
| Product Citations | Inaba, S. et al. (2005). Specific binding of amyloid‐β‐protein to IMR‐32 neuroblastoma cell membrane J. Peptide Res. 65, 485. https://doi.org/10.1111/j.1399-3011.2005.00250.x Qingyou, Li et al. (2004). Overcoming Antigen Masking of Anti-Amyloidbeta Antibodies Reveals Breaking of B Cell Tolerance by Virus-Like Particles in Amyloidbeta Immunized Amyloid Precursor Protein Transgenic Mice |
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